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pentobarbital will lower the extent or effect of piroxicam by affecting hepatic enzyme CYP2C9/ten metabolism. Slight/Importance Mysterious.pentobarbital will minimize the extent or outcome of artemether/lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with sturdy CYP3A4 inducer